The SEMA7A Antibody from MyBioSource.com is a Rabbit Polyclonal antibody to SEMA7A. This antibody recognizes Human, Mouse, and Rat antigen. The SEMA7A Antibody has been validated for the following applications: ELISA, Immunocytochemistry, Immunofluorescence, and Western Blot.
Description
Function: Plays an important role in integrin-mediated signaling and functions both in regulating cell migration and immune responses. Promotes formation of focal adhesion complexes, activation of the protein kinase PTK2/FAK1 and subsequent phosphorylation of MAPK1 and MAPK3. Promotes production of proinflammatory cytokines by monocytes and macrophages. Plays an important role in modulating inflammation and T-cell-mediated immune responses. Promotes axon growth in the embryonic olfactory bulb. Promotes attachment, spreading and dendrite outgrowth in melanocytes.
Subunit Structure: Interacts with ITGA1 and ITGB1 (Probable). Interacts with PLXNC1.
Similarity: Belongs to the semaphorin family